What is the Main Culprit?
The changes you’re experiencing during perimenopause are mainly due to hormonal fluctuations. This means that oestrogen levels can swing wildly while progesterone levels drop significantly.
The Real Problem Isn’t “Low Hormones” — It’s Hormone Chaos
In perimenopause, your ovaries don’t switch off neatly. Instead, they become erratic. This leads to:
Oestrogen surging high one month, crashing low the next
Progesterone steadily dropping due to irregular ovulation
Brain chemistry being affected (serotonin, dopamine, cortisol)
This hormonal rollercoaster is what causes most perimenopause symptoms — not a simple “hormone deficiency”.
Why This Causes So Many Symptoms
Because oestrogen and progesterone affect almost every system in your body, this instability can trigger:
Anxiety & panic attacks
Low mood & sudden rage
Brain fog & memory problems
Insomnia
Palpitations
Hot flushes & night sweats
Weight gain (especially around the middle)
Joint pain
Breast tenderness
Heavy or irregular periods
Fatigue & burnout feelings
Many women feel like they’re “losing their mind” — when in reality, it’s their nervous system reacting to hormone swings.
In Simple Terms:
Progesterone = calming hormone → drops first
Oestrogen = stimulating hormone → becomes erratic
Result = an overstimulated, unsettled nervous system
That’s why perimenopause often feels worse than menopause itself.
Why Some Women Are Hit Much Harder Than Others
There is no single “type” of woman who struggles in perimenopause. However, certain factors make symptoms more intense and more disruptive.
Some women are simply more sensitive to hormone fluctuation. It’s not how high or low your hormones measure — it’s how strongly your brain and nervous system react to the change. This is why:
Blood tests often look “normal”
Yet symptoms can be severe
Doctors may wrongly dismiss women as “okay”
Anxiety, Depression & Mental Health
This is one of the most misunderstood and misdiagnosed areas of women’s health.
Oestrogen = Brain Chemistry Control
Oestrogen directly regulates:
Serotonin (mood stability)
Dopamine (motivation & pleasure)
GABA (calmness)
Cortisol (stress hormone)
When oestrogen swings violently (which it does in perimenopause), the brain can no longer regulate these chemicals properly.
Why Anxiety Often Comes First
Progesterone is your natural calming, sedating hormone. It:
Supports sleep
Reduces anxiety
Keeps the nervous system settled
During this time ovulation becomes irregular → progesterone drops → anxiety skyrockets.
This is why many women experience:
Panic attacks
Night-time anxiety
Health anxiety
Sudden irrational fear
A constant “wired but exhausted” feeling
Even women who were calm their entire lives.
Clear Takeaway
The main culprit = hormonal instability
The hardest hit women = those with hormone sensitivity, stress overload, mental health history, nutrient depletion, or medical conditions
Mental health symptoms = often hormonally driven, not psychologically created
Supplements = support
HRT = treats the root cause